Ion selective electrode approach for in-line determination of benzydamine hydrochloride in different matrices of pharmaceutical industry

This work demonstrates a comparative study between six fabricated ion selective electrode sensors to determine benzydamine hcl (bz) by direct potentiometry in pure form and in its different pharmaceutical formulations. precipitation based technique was only used for fabrication of bz/phosphotungestate (bz/pt) sensor,where bz was incorporated in the membrane composition. for other sensors,the bz association complexes with different cationic exchangers were obtained in situ by soaking the sensors membranes in 1×10-2 m bz solution. sensors 1-5 were named bz/na-tetraphenylborate,bz/phosphomolybdate,bz/na-phosphotungestate,bz/k-tetrakis and bz/ammonium-reineckate,respectively. dioctylphthalate (dop) and nitrophenyloctyl ether (nope) were used as plasticizers. the proposed sensors showed fast,stable nernstian responses across a relatively wide bz concentration range (5×10-5 to 1×10-2 m) in ph range of 4-7. the suggested sensors could be used for several weeks without any measurable change in sensitivity. validation of the method according to iupac recommendations showed the suitability and selectivity of these electrodes in the quality control assessment of bz in presence of different interferents. sensor 4 showed the best results regarding sensitivity and accuracy. the proposed sensors were successfully applied for the determination of bz in pure powder form and in its different pharmaceutical formulations where good recoveries were obtained. © 2017 by cee (center of excellence in electrochemistry).