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All solid sate potentiometric sensors for granisetron hydrochloride in pharmaceutical formulation
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نویسنده
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faridbod f. ,ebrahimi m. ,pirali-hamedani m.
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منبع
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analytical and bioanalytical electrochemistry - 2017 - دوره : 9 - شماره : 2 - صفحه:232 -244
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چکیده
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Granisetron content of some pharmaceutical tablets was determined using a novel all-solid-state polymeric-membrane-electrode (ass-pme) having a sensing element functioning based on an ion-exchange mechanism. the best results were observed with ass-pmes containing 8% gst-tetrakis (p-chlorophenyl) borate as the ion-pair,56% of dibutyl phthalate,31% of poly(vinyl chloride),3% of an ionic liquid and 2% of kpcltpb. the ass element of the device was a conductive composite of graphite,mwcnts,and an epoxy resin coated on a copper wire,and the pvc membranes were coated on the ass. the ass-pme showed a nernstian response of 58.1±0.2 mv/decade over the range of 1.0×10-6 to 1.0×10-3 m. the application of the device was validated and the method was found to be applicable in the analysis of granisetron hydrochloride in pharmaceutical formulations. © 2017 by cee (center of excellence in electrochemistry).
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کلیدواژه
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All solid state; Granisetron; Pharmaceutical formulation; Polymeric membrane; Potentiometry; Sensor
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آدرس
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center of excellence in electrochemistry,school of chemistry,college of scienc,university of tehran,tehran,iran,biosensor research center,endocrinology & metabolism molecular-cellular sciences institute,tehran university of medical sciences, ایران, center of excellence in electrochemistry,school of chemistry,college of scienc,university of tehran, ایران, department of medicinal chemistry,faculty of pharmacy,tehran university of medical sciences,tehran,iran,pharmaceutical sciences research center, ایران
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Authors
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