Potentiometric detection of Clobutinol Hydrochloride level using PVC membrane sensor and relative electronic circuit

A potentiometric inexpensive sensor has been designed for detection of clobutinol hydrochloride level,which is used for curing non-productive coughs. the sensor is capable of doing direct detection of the drug level in the chemical solution using pvc ion-exchange membranes. the ion pair used as the sensing element was made through the interaction of clobutinol hydrochloride and sodium tetra-phenyl borate. it is shown that the highest ion-selective electrodes in sensitivity were achieved by 10% ion pair,45.5% dioctyl phthalateand 44.5% of pvc composition. the sensor response time is found to be less than 10 seconds,with a minimum detectable range of 4.0×10-6m in 0.5×10-1m−1.0×10-5 m range. for measurements,a sensing board in direct and permanent contact with the electrodes is used. this integrated measurement system is made of an atmega16l micro-controller sampling,analyzing and data storage section which makes measurements easier and faster. it also helps with reducing the side effects caused by a traditional multimeter usage such as connection cables resistance. © 2015,the authors.