A sensitive simultaneous determination of epinephrine,Mefenamic acid and acetaminophen using a nickel hydroxide nanoparticles/multiwalled carbon nanotubes modified electrode

The electro-oxidation of epinephrine (epi),acetaminophen (act) and mefenamic acid (mef) has been investigated by application of nickel hydroxide nanoparticles / multi-walled carbon nanotubes modified glassy carbon electrode (mwcnt-nhnps/gce) using cyclic voltammetry (cv),differential pulse voltammetry (dpv) and chronoamperometry (ca) methods. the modified electrode showed suitable electrochemical responses for epi,act and mef determination. under the optimum conditions the electrode provides a linear response versus epi,act and mef concentrations in the range of 0.5-180 μm,0.1-180 μm,and 0.1-85 respectively using the dpv method. application of ca method showed linear responses for epi and act concentrations in the range of 1-600 μm and 1-500 μm respectively. the ca results for mef showed two linear range of 1-50 μm and 60-600 μm. the modified electrode was used for determination of epi,act and mef in human serum and urine with satisfactory results. © 2015,the authors.