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Electroanalysis in the Evaluation of Nanoparticle Toxicity
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نویسنده
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Kozitsina Alisa ,Pomorceva Ekaterina ,Suntsova Yulia ,Beykin Jakov ,Lagereva Yulia ,Tulakina Ludmila ,Matern Anatoly ,Brainina Khiena
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منبع
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analytical and bioanalytical electrochemistry - 2013 - دوره : 5 - شماره : 5 - صفحه:647 -664
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چکیده
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An increasing use of nanomaterials requires careful assessment of their toxicity, ways of biological interactions, and possible consequences for living organisms. a variety of nanomaterials and fragmented studies of nanomaterial toxic effects on living organisms have led to contradictory views on their safety. the article proposes a potentiometric method of evaluating antioxidant activity of biological systems, which gives an indication of oxidative stress. cell lines wi-38 and l20b, introduced with gold and silver nanoparticles, were used as samples. the work demonstrates a correlation between cell viability, cytokine status, the level of antioxidant activity and concentrations of ag and au nanoparticles, absorbed by cells. determination of the quantity of nanoparticles absorbed by cells and antioxidant concentration in cells can serve as optional methods of assessing a negative impact of nanoparticles on living substrates
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کلیدواژه
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Potentiometric method ,Oxidative stress ,Antioxidant activity ,Electron microscopy studies ,Cell culture ,Nanoparticles of noble metals ,Stripping voltammetry
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آدرس
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Ural Federal University, Department of Analytical Chemistry,Ural Federal University named after the first President of Russia B N Yeltsin, Mira Street 19, 620002Ekaterinburg,, Russia, Ural State Economic University, Department of Chemistry and Physics, Ural State Economic University, 8th March Street 62, 620144 Ekaterinburg, Russia, Russia, Ural Federal University, Department of Analytical Chemistry,Ural Federal University named after the first President of Russia B N Yeltsin, Mira Street 19, 620002Ekaterinburg,, Russia, Clinical and Diagnostic Centre, Institute of immunology and physiology of the Ural branch of Russian Academy of Sciences, Clinical and Diagnostic Centre, Furmanova Street 115A, 62014, Russia, Clinical and Diagnostic Centre, Institute of immunology and physiology of the Ural branch of Russian Academy of Sciences, Clinical and Diagnostic Centre, Furmanova Street 115A, 62014, Russia, Clinical and Diagnostic Centre, Institute of immunology and physiology of the Ural branch of Russian Academy of Sciences, Clinical and Diagnostic Centre, Furmanova Street 115A, 62014, Russia, Ural Federal University, Department of Analytical Chemistry,Ural Federal University named after the first President of Russia B N Yeltsin, Mira Street 19, 620002Ekaterinburg,, Russia, Ural Federal University, Department of Analytical Chemistry,Ural Federal University named after the first President of Russia B N Yeltsin, Mira Street 19, 620002Ekaterinburg,, Russia
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Authors
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