Ag/TiO2 Nanocomposite Modified Carbon Paste Electrode used to Differential Pulse Voltammetric Determination of Carbamazepine

Ag/tio2 nanocomposite was used as a modifier in carbon-paste electrode (cpe) tofabricate a carbamazepine (cbz) voltammetric sensor. the results show an efficient catalyticactivity of the electrooxidation of cbz. electrochemical behaviour of cbz at the sensor wasstudied by cyclic voltammetry (cv) and differential pulse voltammetry (dpv). resultsshowed that the modified electrode exhibited a strong electrocatalytic activity toward theredox of cbz. the effects of scan rate and ph on peak current were investigated and anoptimal scan rate of 50 mv s-1 and a ph 2.0, britton-robinson buffer solution (br), wereused. under the optimum conditions, the catalytic peak currents of cbz were linearlydependent on the concentrations of cbz in the range from 2.5×10-6 to 1.0×10-4 mol l-1 with adetection limit of 8.6×10-7 mol l-1. this proposed method was successfully applied todetermine the carbamazepin concentration in its tablet as real sample and a recovery of 95%was obtained without interference from tablet matrix.