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Application of Membrane Selective Electrodes for the Determination of Azelastine Hydrochloride in the Presence of its Alkaline Degradant in Eye Drops and Plasma
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نویسنده
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Elghobashy Refaat Mohamed ,Badran Mohamed Osama ,Salem Yacoub Maissa ,Kelani Mohamed Khadiga
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منبع
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analytical and bioanalytical electrochemistry - 2013 - دوره : 5 - شماره : 3 - صفحه:325 -340
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چکیده
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Azelastine hydrochloride (azt) was described by using the ion associationcomplex between these drugs with either sodium tetraphenyl-borate (tpb) or ammoniumreineckate (rnc) counter ions. the performance characteristics of the sensors were evaluatedaccording to iupac recommendations, reveal a fast, stable and linear response over theconcentration range 10-5- 10-2 m for azt. the sensors are used for determination of azt ineye drops and plasma. the developed method was found to be simple, accurate and precisewhen compared with the manufacturer method.
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کلیدواژه
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Azelastine Hydrochloride ,Ion Selective Electrode ,PVC Membranes Ammonium Reineckate ,Sodium Tetraphenyl-Borate
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آدرس
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Analytical chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., ET-11562 Cairo, Egypt, Egypt, Analytical chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., ET-11562 Cairo, Egypt, Egypt, Analytical chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St.,Egypt, Egypt, Analytical chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St.,Egypt, Egypt
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Authors
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