Potentiometric Method for the Determination of Lamivudine and Dothiepin Hydrochloride in Pharmaceutical Preparations

A simple and accurate potentiometric titration method for the determination oflamivudine and dothiepin hydrochloride is developed. for this purpose, two n-bromoimides,viz., n-bromosuccinimide (nbs) and n-bromophthalimide (nbp) were used as titrants fordetermination of the two drugs in acid medium and the end point is determined using aplatinum indicator electrode. the method was successfully applied for the determination oftwo drugs in their pure state or pharmaceutical preparations with mean recovery values of99.67-100.10 and 99.55-100.33% and relative standard deviations (rsd) were 0.16-0.38 and0.29-0.58% for lamivudine and dothiepin hydrochloride, respectively. statistical comparisonof the results with official and reported methods showed excellent agreement.