Conductomtric Determination of Torasemide in Bulk Drug, in Formulations and in Plasma

Two simple and sensitive conductometric procedures were investigated for thedetermination of torasemide (tos) using potasium tetraphenyl borate (k tpb) andammonium reineckate (amm. rnc) were described. optimized conditions includingtemperature, solvent and reagent concentration were studied. the suggested methods wereused for conductometric determination of (tos) in its pharmaceutical preparations.precision, measured as relative standard deviation was less than 1% and accuracy was 99.76%.the obtained results were comparable with data using the reported method. the proposedprocedures were successfully adapted for the determination of (tos) in plasma. forcomparison, some interference was also determined by the condutometric titrations. atequimolar concentration levels, some molecules of similar structure interfere with the originaldrug. a reduction in interferent concentration by a factor of 10 negated the interference