Novel Ion Selective Electrode for Determination of Pregabalin in Pharmaceutical Dosage Form and Plasma

Ion selective electrode technique was developed for determination of pregabalin.the key to construct such an electrode is to produce a sensitive and selective membrane thatresponds to a particular ionic species. such membrane is usually prepared by in corporatingan appropriate ion exchanger and solvent mediator into a poly (vinyl chloride) or (pvc)membrane matrix. the present work originates from the fact that pregabalin behaves as acation in 0.1 n hcl solution and forms a precipitate with anionic potassium tetrakisp-chlorophenyl borate which used in fabrication of the membrane sensor. the potentiometricresponse was linear with constant slope over a drug concentration range of10-6–10-3 m with slope of 53±1 mv/decade .the developed method was applied successfullyfor the determination of pregabalin in the pure powder form, pharmaceutical formulation andin spiked human plasma without any interference.