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Novel Potentiometric Determination of Torasemide for Antidoping Purpose, Using B-Cyclodextrin and Calixarene
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نویسنده
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El-Kosasy M. Amira ,El-Aziz Abd Omar ,Ebrahim Naglaa ,Fattah Abdel Laila
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منبع
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analytical and bioanalytical electrochemistry - 2012 - دوره : 4 - شماره : 4 - صفحه:357 -371
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چکیده
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Two novel torasemide (tor) sensors were investigated, using b-cyclodextrin andcalix[4]arene as ionophores, where linear responses within concentration ranges of (10-7-10-2and 10-8-10-2m) and nernstian slopes of (58.77 and 59.214 mv/decade) over the ph range of7-12 were obtained, respectively.the selectivity coefficients of the developed sensorsindicate excellent selectivity for tor, where the second sensor shows a higher sensitivity ifcompared to the first one. the proposed fabricated sensors display useful analyticalcharacteristics for the determination of tor (for anti-doping purpose) in bulk powder,biological fluids and in pharmaceutical formulation.
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کلیدواژه
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Torasemide ,B-cyclodextrin ,Calix[4]arene ,Potentiometry ,Antidoping ,Plasma ,Urine
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آدرس
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Ain Shams university, bPharmaceutical Analytical Chemistry Department, Faculty of pharmacy, Ain Shams university, Abbassia, Cairo, Egypt, Egypt, Pharmaceutical Analytical Chemistry Department, Faculty of pharmacy, Ain Shams, university, Abbassia, Cairo, Egypt, Egypt, Pharmaceutical Analytical Chemistry Department, Faculty of pharmacy, Ain Shams,university, Abbassia, Cairo, Egypt, Egypt, Pharmaceutical Analytical Chemistry Department, Faculty of pharmacy, Misr university for science and technology,6thOctober, Giza, Egypt, Egypt
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Authors
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