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Validation of Selective Electrochemical Method for Determination of Sumatriptan in Combined Dosage Form
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نویسنده
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Rezk R. Mamdouh ,Michael M. Adel ,Lotfy M. Hayam ,Shehata A. Mostafa
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منبع
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analytical and bioanalytical electrochemistry - 2012 - دوره : 4 - شماره : 6 - صفحه:553 -563
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چکیده
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A novel sumatriptan (sum) selective electrode was investigated with dioctylphthalate as a plasticizer in a polymeric matrix of carboxylated polyvinyl chloride (pvccooh),based on the interaction between the drug solution and the dissociated coohgroups in the pvc-cooh. the sensor was fabricated by using pvc-cooh only as anionicsite without incorporation of an ionophore. linear response of sum within a concentrationrange of 10-6-10-3 m with a slope of 34±1 mv/decade over ph range of 6-8 was observed.the measurement was characterized by a fast stable response within about 45 seconds.theproposed sensor was successfully applied for the selective determination of sumatriptanin thepure powder form and in its pharmaceutical formulation with naproxen without anyinterference. the results obtained by the proposed procedure were statistically analyzed andcompared with those obtained by the u.s. pharmacopeia method. no significant differencefor either accuracy or precision was observed.
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کلیدواژه
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Sumatriptan ,Ion Selective Electrode ,Carboxylated PVC ,Pharmaceutical
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آدرس
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Cairo University, Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt, Egypt, Ahram Canadian University, Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University,Egypt, Egypt, Cairo University, 1Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt, Egypt, Cairo University, Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt, Egypt
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Authors
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