Voltammetric Determination of Paracetamol with Poly(3,4-Ethylenedioxythiophene) Modified Glassy Carbon Electrode

This study describes the preparation and application of a poly(3,4-ethylenedioxythiophene) (pedot) modified glassy carbon electrode for paracetamoldetermination in pharmaceutical samples. the pedot modified electrode was preparedby electropolymerizing 3,4-ethylenedioxythiophene (edot) on a glassy carbon electrodein a non-aqueous medium. the best performance of the pedot modified electrode in 0.1mol l-1 phosphate buffer obtained at ph 7.0. under these conditions, an oxidationpotential of paracetamol was observed at 0.37 v versus ag/agcl/sat’d kcl. the cyclicvoltammetric study indicates that the pedot modified electrode shows a very goodelectrocatalytic activity by reducing the overpotential by 200 mv for paracetamoloxidation. the modified electrode showed a linear response range between 2.5 and 150?mol l-1, a sensitivity of 90.03 ?a/mmol l-1, quantification and detection limits of 2.5?mol l-1 and 1.13 ?mol l-1, respectively. finally, the proposed method was applied forparacetamol determination in commercial tablets with a mean recovery of (101?6) %.