Enhancement of Sensitivity of Molecularly Imprinted Polymer Based Parathion Voltammetric Sensor by Using Experimental Design Techniques

Molecularly imprinted polymer (mip), having recognition sites for parathion,was used for carbon paste electrode fabrication and then used as a voltammetric sensorfor parathion determination. different factors including electrode composition,conditions of parathion extraction in the electrode and electrochemical measurementparameters were evaluated and then optimized by using various techniques of screeningand response surface experimental design. after optimization, very high sensitivity andsub-nanomolar detection limit were obtained successfully. it was shown that the sensorresponse for parathion concentration was linear in the range of 0.3-710 nm. detectionlimit of designed sensor was calculated equal to 0.07 nm. it was shown that theapplication of multivariate optimization method instead of traditional optimizationmethod led to considerable improvement in the final sensor performance.