Analytical Determination of Paracetamol in Human Blood by Improving the Catalytic Effect of a Clay-Based Electrode

In this work, we investigated the applicability of the clay-modified carbon paste electrode (cpe- clay) in the detection of paracetamol (par), using two electrochemical methods: differential pulse voltammetry (dpv) and cyclic voltammetry (cv) in the range between 20 and 400 mv in a britton robinson buffer solution (ph 7). the voltammetric technical behavior of par is studied where a sensitive anodic and cathodic peak has been appeared at about 0.4 v and 0.2 v (vs. ag/agcl/3 m kcl) successively. these peaks were recorded from the reversible redox of par at the cpe-clay surface. the proposed technical (dpv, cv) exhibits remarkably an electro-catalytic success for par redox. the current response of the catalytic peaks obtained by dpv depended linearly on the concentration of par in the range between 1.0 × 10^-6 and 1.0 × 10^-3 mol l^-1 with a detection limit of 5.27 × 10^-9 mol l^-1. subsequently, the relative standard deviation (rsd) at 1.0 × 10^-4 mol l^-1 par concentration was 3.8% for nine replicates. the proposed electrode has been successfully used for par detection in the human blood sample.