Synthesis of Pt-SWCNTS Conductive Nanocomposite by Microwave Heated Polyol Strategy; Application for Amplification of 5-Fluorouracil Anticancer Drug Electrochemical Sensor

In this study, a simple strategy was described for the synthesis of pt-swcnts conductive nanocomposite by microwave heated polyol method and nanocomposite characterized by eds, fesem, and xrd method. the pt nanoparticles were decorated at the surface of swcnts with a diameter of 22.3 nm. the synthesized nanocomposite was used for modification of the carbon paste electrode (cpe) in the presence of n-hexyl-3-methylimidazolium hexafluorophosphate (nh3mhp) and paraffin oil as binders. the pt-swcnts/nh3mhp/cpe was showed a good catalytic effect for electro-oxidation of the 5-fluorouracil anticancer drug in aqueous solution. in comparison to cpe, the pt-swcnts/nh3mhp/cpe increased oxidation current of 5-fluorouracil (⁓4.47 times) and reduce oxidation potential of this anticancer drug ⁓125 mv. on the other hand, pt- swcnts/nh3mhp/cpe was successfully used for the determination of 5-fluorouracil anticancer drugs in injection samples with acceptable recovery data (96.13%-103.5%). according to recorded results, the sensor has a powerful tool for determination of 5-fluorouracil anticancer drug in real samples.