Determination of Copper Content of Human Blood Plasma by an Ion Selective Electrode based on a New Copper-Selectophore

A new selectophore was introduced for cu^2+ ions. spectroscopic studies showed a selectivity of a new organic compound (l) toward copper ions and several transitional metal ions. hence, l was utilized in designing several ion selective electrodes for these cations. in practice, cu^2+ ion selective electrode behaved nernstian (slope of 27.95±0.3 mv decade^-1) over a wide linear range of 1.0×10^- 6-1.0×10^-2 mol l^-1. optimum performance of the indicator electrode was observed by a membrane containing 7% selectophore, 2% sodium tetraphenyl borate (natpb) as an ionic additive, 61% nitrobenzene (nb) as solvent mediator and 30% polyvinyl chloride (pvc). the sensor showed a short response time of about 20 s and an acceptable life time, the potentiometric response is independent on the ph of the solution in the range of 3.5-7. the optimized copper sensor was used for analysis of copper content of some blood plasma samples. the obtained results were in good agreements with icp-oes method.