A Biomimetic Potentiometric Membrane Sensor using Molecularly Imprinted Nano-Polymer for Furosemide Drug Analysis

A potentiometric sensor was made using a non-covalent imprinted nano-polymer for analysis of furosemide pharmaceutical compound. furosemide is a diuretic drug which is also categorized among the doping agent. the nano-molecularly imprinted polymer (nano-mip) was prepared through precipitation polymerization, where furosemide was used as a template molecule, acryl amid (aa) as a functional monomer and ethylene glycol dimethacrylat (egdma) as a cross-linking agent. the sensor showed a selective and sensitive response to the analyte (the template molecule) in aqueous solutions. the mip-based sensor responded nernstian (51.8±0.3 mv decade^−1) in a concentration range of 7.5×10^-6 to 1.0×10^-1 mol l^-1 with a lower detection limit of 5.0×10^-6 mol l^-1. the response time of the sensor was ∼20 s, a high performance and a satisfactory long-term stability (more than 2 months). the proposed sensor has acceptable accuracy, sensitivity and precision to be used for furosemide assay in some pharmaceutical preparations.