A Molecularly Imprinted Polymer (MIP)-based Biomimetic Potentiometric sensing device for the analysis of Clarithromycin

A molecular imprinted polymer (mip)-based biomimetic sensing device was constructed for the analysis of clarithromycin (cm). the novel mip was prepared using a methacrylic acid (maa) (functional monomer) and ethylene glycol dimethylacrylate (egdma) (cross-linker) and the target species (i.e.cm) as the template molecule. the resulting mip had considerable adsorption capacity and excellent selectivity toward cm compound. after some experiments, optimum 1:6 mole ratio of template to maa was selected for the synthesis of cm mip. the non-covalent cm-mip was used for the construction of a potentiometric sensor for cm. the proposed had selective and sensitive response to cm concentration in aqueous media. the electrode response had a nernstian response of 50.8±1.0 mv decade−1 from 1.0×10^-6 to 5.0×10^-3 m and had a detection limit as low as 8.0×10^-7 m. the response time of the electrode was about 15 s, and it had a long-term stability of over 45 days. the sensor also proved applicable to the analysis of cm concentration in tablets with good sensitivity and accuracy.