Monitoring of Risperidone in Pharmaceutical Formulations by a Novel Solid-Contact PVC Membrane Potentiometric Sensor

Risperidone (rsp) is an antipsychotic medication commonly used in the treatment of schizophrenia, schizoaffective and some forms of bipolar disorder. a novel rsp all-solid state potentiometric membrane electrode (ass-pme) was introduced for assay of risperidone active ingredient in dosage forms. the ass-pme was made of a copper wire coated with a layer of conductive graphite-epoxy resin, a layer of carbon dots and finally a pvc sensing layer. the pvc layer was composed of 30% of pvc, 61% of dibutylphthalate (dbp) as solvent mediator, 2% of an ionic additive (sodium tetraphenyl borate (natpb)) and 7% of an ion-pair of rsp-tpb as a sensing material. the device worked well under laboratory condition and showed a nernstian response of 58.2±0.4 mv/decade from 1.0×10^-7 m to 1.0×10^-3 m of the analyte with lower detection limit of 8.3×10^-8 m. the ass-pme has excellent selectivity toward ris in presence of excipients in its pharmaceutical dosage forms.