Application of Cu(II) Nanocomplex Modified Graphite Screen Printed Electrode to Improve the Sensitivity for Norepinephrine Detection

A cu(ii) nanocomplex, [cucl_2(salophen)]. h_2o [salophen=o-phenylenediaminebis (salicylidenaminato)], was synthesized. the electrochemical properties of the as-prepared cu(ii) nanocomplex modified graphite screen printed electrode (cu/spe) were investigated using cyclic voltammetry (cv) and differential pulse voltammetry (dpv). moreover, as a nanosensor for the determination of norepinephrine the cu/spe exhibited excellent electrocatalytic activity for the oxidation of norepinephrine with a faster electron-transfer rate. the dpv technique was used for the trace determination of norepinephrine. the dependence of current vs. concentration was linear from 0.3 to 300.0 μm with a regression coefficient of 0.9992, and the detection limit of norepinephrine was 0.09 μm. finally, the method was applied to the selective and precise analysis of norepinephrine in norepinephrine injection.