Potentiometric Determination of Salbutamol using Carbon Paste Electrode Assisted with Multi-Walled Carbon Nanotubes

Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (copd). in this work a salbutamol selective nanocomposite sensor based on ion-pair as a sensing element, multi-walled carbon nanotubes (mwcnts), graphite powder and paraffin oil is constructed. the optimized composition of 7% mwcnts, 20% ionophore, 20% paraffin oil and 53% graphite powder shows a nernestian response of 29.1±0.4 in the range of 5×10-6^-1×10^-2 mol l^-1. multi-walled carbon nanotubes are used because of electrical conductivity and remarkable mechanical strength. the proposed carbon paste electrode can be used over the ph range of 3.5–10 and has a detection limit of 3.0×10^-6 mol l^-1. this method is used to salbutamol recognition in pure solutions and pharmaceutical preparations with high accuracy and precision.