Comparison of efficacy of intralesional 5-fluorouracil alone versus intralesional triamcinolone acetonide with 5-fluorouracil in small keloids

Objective to evaluate the efficacy of intralesional 5-fluorouracil alone in comparison with the combination of intralesional triamcinolone acetonide and 5-fluorouracil in treatment of small keloids. methods sixty patients who fulfilled the inclusion and exclusion criteria were recruited. patients were randomly divided into two groups. in group a,intralesional 5-fluorouracil 50 mg/ml was used. in group b,combination of triamcinolone acetonide 40mg/dl (0.1ml) and 5-fluorouracil 50mg/ml (0.9ml) was used,on monthly basis for 6 months. patients were assessed for efficacy,after 6 months of the treatment. results efficacy was achieved in 32 cases in which 10 (33.3%) cases were from 5-fu group and 22 (73.3%) were from 5-fu+steroid group,which was statistically significant (p=0.002.). conclusion in the treatment of small keloids the combination of 5-fu + steroid has better efficacy in comparison with 5-fu alone.