An autoimmune quandary: Discoid lupus erythematosus and HIV coexistence in an Indian patient

The development of autoimmune diseases in the backdrop of an immune dysfunction in patients with human immunodeficiency virus (hiv) infection is intriguing. an infectious trigger for immune activation is one of the postulated mechanisms and derives from molecular mimicry. progression from hiv infection to aids is associated with a gradual loss of immune-competence. immune dysregulation and persistent,prolonged immune activation leads to autoimmune phenomena such as lupus and serological abnormalities. we report this sui generis case of discoid lupus erythematosus in hiv positive indian male for its sheer clinical charm. we also discuss on the probable etiopathogenesis which has not been confounded together so far.