Hydroxyurea – An experience in the management of psoriasis

Objective: to assess efficacy and safety of hydroxyurea therapy in different types of psoriasis. patients and methods: eighty patients of chronic plaque psoriasis, generalized pustular psoriasis with more than 20% body surface area and psoriatic erythroderma were included in the prospective nonrandomized study. results: at least good response (up to 50% reduction of pasi) to therapy was noticed in 77.6% (59/76), 11.9% patients did not respond and 10.5% patients worsened. conclusion: hydroxyurea is effective in the treatment of extensive psoriasis with not so serious side effects.