A study on clinical manifestations of tuberous sclerosis

Objective: to document clinical features in patients of tuberous sclerosis. patients and methods: twenty clinically diagnosed cases of tuberous sclerosis were assessed clinically for features of tuberous sclerosis. results: males outnumbered females and male: female ratio was 2.3:1. adenoma sebaceum was the commonest (95%) cutaneous feature of tuberous sclerosis followed by ash leaf macule and shagreen patch each seen in 90% patients followed by koenen’s tumour seen in 75% patients. positive family history was seen in 25% patients. regarding the clinical spectrum of tuberous sclerosis it was seen that epileptic fits and cardiac complications were seen in 50% patients each, eye abnormalities including retinal astrocytomas were seen in 40% patients, mental retardation was seen in 25% patients followed by astrocytomas and pulmonary disease seen in 20% patients each. conclusion: tuberous sclerosis can present with diverse cutaneous and systemic manifestations. dermatologist may assist in early diagnosis of this multisystem genodermatosis.