Treatment of small keloids with intralesional 5- fluorouracil alone vs. intralesional triamcinolone acetonide with 5-fluorouracil

Background keloid is a benign well demarcated area of dense, fibrous tissue overgrowth that extends beyond the original defect. objective to compare the efficacy of intralesional 5-fluorouracil (5-fu) alone vs. intralesional triamcinolone acetonide (tac) in combination with 5-fluorouracil. patients and methods study on 50 clinically diagnosed lesions of keloids from 28 patients was conducted. in group a, 25 keloid lesions were subjected to 50 mg/ml 5-fu intralesionally while in group b, 25 keloid lesions were injected intralesionally with a combination of 40 mg/ml triamcinolone acetonide (0.1 ml) and 5-fu 50mg/ml (0.9 ml). both the procedures were repeated at weekly intervals for 4 weeks, then bimonthly for 2 months and then monthly until the keloid lesions in both groups virtually assumed the same level as that of surrounding tissue or for a maximum of 3 months. results good to excellent response was seen in 96% cases in group b in contrast to 72% cases only in group a. the group b lesions showed better improvement than group a lesions in pruritus, pain, tenderness, restriction of movements and cosmetic problem. no recurrence was seen in any of the lesions. conclusion the combination of 5-fu and triamcinolone acetonide is a better modality of treatment of small keloids compared with 5-fu alone