بررسی القای آپوپتوز ناشی از نانوکورکومین پلیمری در رده سلولی سرطان معده ( (AGS

Background: gastric cancer is known as the 4th cause of malignancyand mortality in the world. several risk factors have been defined for thismalignancy as diet and environmental factors. curcumin is a herbal derivatewhich has obvious effects on suppression of malignancies via inhibition ofapoptosis, cell proliferation, invasion and angiogenesis. it has also been shownthat curcumin has no adverse effect on body normal cells. the most importantlimitation factor in its clinical use is being water insoluble, low absorption rateand bio-instability. the aim of this study was to use dendrosomes as carriersof curcumin and to study the induction of apoptosis on ags cells.materials and methods: in this study, ags cells have been exposed todifferent concentrations of polymer nano curcumin (5 to 20 micromole).metabolic activity of these cells has been evaluated by using mtt test. alsoapoptosis has been studied using annexin test.results: this study showed that nano curcumin concentration of 13 micromoleis able to suppress metabolic activity of 50% of cellules and also to suppressapoptosis in 26% of them in compare with control group.conclusion: the concentration of encapsulated agent that may lead toinhibition of metabolic activity and apoptosis is too low. as dendrosomeshave been shown to be non-toxic on body cells and also the amount of freecurcumin which is needed to have effects like this study is too high, it looksthat 13 micromole concentration of nano curcumin polymer has significantbetter effect on clinical targets in compare with free form.keywords: polymer nano curcumin, apoptosis, gastric cancer, drugconcentration