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   Essential Oil Analysis and Antibacterial Activity of Ferula Assa-Foetida L. Aerial Parts From Neishabour Mountains  
   
نویسنده Samadi N. ,Shahani S. ,Akbarzadeh H. ,Mohammadi-Motamed S. ,Safaripour E. ,Farjadmand F. ,Eftekhari M. ,Monsef-Esfahani H.R. ,Khanavi M.
منبع Research Journal Of Pharmacognosy - 2016 - دوره : 3 - شماره : 3 - صفحه:35 -42
چکیده    Background and objectives: ferula assa-foetida (asafoetida) is a native iranian species which grows in different regions and climates in iran. the plant is well known in iranian traditional medicine as well as folk medicine for treatment of diseases. several studies have been carried out on the essential oil of this species collected from different areas of iran. this study is the first report about the essential oil of the plant collected from neishabour mountains that is a potent area for growing this valuable plant species. methods: essential oil of the aerial part of ferula assa-foetida which was collected from neishabour, iran, was analyzed by gas chromatography-mass spectroscopy (gc/ms). the minimum inhibitory concentrations of the essential oil was investigated against both gram-positive (staphylococcus epidermidis, staphylococcus aureus, bacillus subtilis) and gram-negative (escherichia coli, pseudomonas aeruginosa, klebsiella pneumonia) bacteria using microdilution method. results: twenty three components representing 97.06% of the total oil were identified. (e)-1-propenyl sec-butyl disulfide (53.77%), (z)-1-propenyl sec-butyl disulfide (35.6%) and ?-pinene (3.4%) were identified as major components. the mic of the essential oil ranged from 12-24 mg/ml against all tested bacteria. conclusion: the results indicated that among various compounds identified in the essential oil of f. assa-foetida l. from neishabour mountains, disulphide compounds were the major constituents of the oil. in comparison to other reports of this plant around the country, disulphide compounds could be the reason of its moderate antibacterial effect.
کلیدواژه Antibacterial Activity ,Essential Oil ,Ferula Assa-Foetida ,Gc/Ms
آدرس Department Of Drug And Food Control, Faculty Of Pharmacy And Pharmaceutical Quality Assurance Research Center, Tehran University Of Medical Sciences, Tehran 14155-6451, Iran, ایران, Department Of Pharmacognosy And Biotechnology, Faculty Of Pharmacy, Mazandaran University Of Medical Sciences, Sari, Iran, ایران, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran 19419-33111, Iran, ایران, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran 19419-33111, Iran, ایران, Department Of Drug And Food Control, Faculty Of Pharmacy And Biotechnology Research Center, Tehran University Of Medical Sciences, Tehran 14155-6451, Iran, ایران, Food And Drug Organization, Ministry Of Health And Medical Education Of Iran & Department Of Traditional Pharmacy, Faculty Of Traditional Medicine, Tehran University Of Medical Sciences, Tehran, Iran, ایران, Department Of Pharmacognosy, Faculty Of Pharmacy And Persian Medicine And Pharmacy Research Center, Tehran University Of Medical Sciences, Tehran14155-6451, Iran, ایران, Faculty Of Land And Food Systems, University Of British Columbia, Vancouver, Bc, Canada, کانادا, Department Of Pharmacognosy, Faculty Of Pharmacy And Persian Medicine And Pharmacy Research Center, Tehran University Of Medical Sciences, Tehran14155-6451, Iran. Faculty Of Land And Food Systems, University Of British Columbia, Vancouver, Bc, Canada, ایران
 
     
   
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