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   evaluation of anti-malarial activity of artemisia turcomanica and a. kopetdaghensis by cell-free b-hematin formation assay  
   
نویسنده mojarrab m. ,emami s.a. ,gheibi sh. ,taleb a.m. ,heshmati afshar f.
منبع research journal of pharmacognosy - 2016 - دوره : 3 - شماره : 4 - صفحه:59 -65
چکیده    background and objectives: the plants of genus artemisia (asteraceae) have been conventionally used for prevention and medication of a number of ailments. in the present research, ten extracts with different polarities from aerial parts of two artemisia species, a. kopetdaghensis and a. turcomanica were evaluated for their potential anti-malarial properties. methods: the plant materials were extracted successively with petroleum ether (pe), dichloromethane (dcm), ethyl acetate (etoac), ethanol, and ethanol-water (1:1 v/v) by cold maceration method. cell free b-hematin formation assay were used for assessing anti-malarial activity of obtained extracts. results: dcm extract of a. kopetdaghensis and pe extract of a. turcomanica showed remarkable anti-malarial activity with ic50 values of 1.04±0.02 mg/ml and 0.90±0.27 mg/ml, respectively, compared to positive control (chloroquine, ic50 0.04±0.01 mg/ml). conclusion: it seems that the anti-malarial activity of these extracts might be bound up with the presence of compounds with low or medium polarity; hence, this preliminary test indicated that these potent extracts could be considered for further investigations to find new sources of anti-malarial phytochemicals.
کلیدواژه anti-malaria ,artemisia kopetdaghensis ,artemisia turcomanica ,cell-free b-hemation formation assay
آدرس pharmaceutical sciences research center, school of pharmacy, kermanshah university of medical sciences, kermanshah, iran, ایران, depertment of pharmacognosy, faculty of pharmacy, mashhad university of medical sciences, mashhad, iran, ایران, pharmaceutical sciences research center, school of pharmacy, kermanshah university of medical sciences, kermanshah, iran, ایران, department of pharmacogenesis, faculty of pharmacy, tehran university of medical sciences, tehran, iran, ایران, drug applied research center, tabriz university of medical sciences, tabriz, iran. department of pharmacognosy, faculty of pharmacy, tabriz university of medical sciences, tabriz, iran, ایران
 
 

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