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   Acetylcholinesterase inhibitory effects of some plants from Rosaceae  
   
نویسنده Esmaeili S. ,Ara L. ,Hajimehdipoor H. ,Kolivand H. ,Mohammadi Motamed S.
منبع research journal of pharmacognosy - 2015 - دوره : 2 - شماره : 4 - صفحه:33 -37
چکیده    Background and objectives: Alzheimer's disease (AD) is an age dependent disorder. AD is associated with decrease of brain acetylcholine level. Nowadays, one of the methods for progression inhibition of AD is using acetylcholinesterase inhibitors. Rosaceae is a large plant family. Different biological effects of some species of this family have been reported. The aim of the present study was to assess the acetylcholinesterase inhibitory (AChEI) activity of the selected plants belonging to Rosaceae family. Methods: AChEI activity of six species from Rosaceae including Cotoneaster nummularia, Cerasus microcarpa, Amygdalus scoparia, Agrimonia eupatoria, Rosa canina and Rosa damascena were evaluated based on Ellman’s method in concentration of 300 µg/mL using total extracts and methanol fractions which were obtained by maceration. Results: The results showed that the total extract and methanol fraction of the aerial parts of A. eupatoria demonstrated significant AChEI activity with 46.5% and 56.2% inhibition of the enzyme, respectively. Conclusion: According to the results of the AChEI activity of the methanol fraction of A. eupatoria, it seems that the polar components of the species such as flavonoids may be responsible for its effectiveness.
کلیدواژه Acetylcholinesterase inhibition ,Agrimonia eupatoria ,Alzheimer ,Ellman’s method ,Rosaceae
آدرس shahid beheshti university of medical sciences, Traditional Medicine and Materia Medica Research Center, ایران, shahid beheshti university of medical sciences, Traditional Medicine and Materia Medica Research Center, ایران, shahid beheshti university of medical sciences, School of Traditional Medicine, Department of Traditional Pharmacy, ایران, shahid beheshti university of medical sciences, Traditional Medicine and Materia Medica Research Center, ایران. Islamic Azad University, Pharmaceutical Sciences Branch, ایران, Islamic Azad University, Pharmaceutical Sciences Branch, ایران
 
 

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