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   Formulation and Quality Control of Prunus Domestica Syrup, Prepared According To Iranian Traditional Medicine  
   
نویسنده Hamzeloo-Moghadam M. ,Danaifar N. ,Mostafavi S. A. ,Hajimehdipoor H.
منبع Research Journal Of Pharmacognosy - 2015 - دوره : 2 - شماره : 2 - صفحه:13 -17
چکیده    Background and objectives: prunus domestica (plum) has been considered as a useful remedy for several disorders in iranian traditional medicine (itm). it has cold and wet temperament and is used as syrup for hot temperament diseases such as hot headache and stomach disorders. in the present study, plum syrup has been formulated according to itm manuscripts and quality control evaluations have been accomplished to present a suitable formulation. methods: the fruits of prunus domestica l. were macerated in water, then decocted. the mixture was filtered. the filtrate was concentrated to have a suitable viscosity. the extract was sweetened by adding sugar (1:2) and heated till sugar was completely dissolved. the final product was evaluated physicochemically and microbiologically according to standard protocols and total phenolics content of the syrup stability was determined. the syrup was assessed in accelerated condition (40 ºc) during 6 months. results: the prepared formulation was a viscose and brown syrup with plum flavor and fragrance. no precipitation and cap locking were observed in the syrup. dry residue, ph, density, viscosity and total phenolics of the syrup were found 43.1%, 3.49, 1.27 g/ml, 6.5 cp and 152.3 mg/100ml, respectively. no microbial growth was observed in the formulation. in the accelerated stability tests, no remarkable changes were seen in the product. total phenolics content was decreased 2.2% during 6 months in 40 ?c. conclusion: the formulated prunus domestica syrup could be introduced for further mass production after completing the final required evaluations.
کلیدواژه Formulation ,Iranian Traditional Medicine ,Prunus Domestica ,Quality Control ,Syrup
آدرس Shahid Beheshti University Of Medical Sciences, School Of Traditional Medicine, Traditional Medicine And Materia Medica Research Center, Department Of Traditional Pharmacy, ایران, Isfahan University Of Medical Sciences, School Of Pharmacy And Pharmaceutical Sciences, Isfahan Pharmaceutical Sciences Research Center, Department Of Pharmaceutics, ایران, Isfahan University Of Medical Sciences, School Of Pharmacy And Pharmaceutical Sciences, Isfahan Pharmaceutical Sciences Research Center, Department Of Pharmaceutics, ایران, Shahid Beheshti University Of Medical Sciences, School Of Traditional Medicine, Traditional Medicine And Materia Medica Research Center, Department Of Traditional Pharmacy, ایران
 
     
   
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