myrtenol protects against acute kidney injury induced by cisplatin in mice

Background and objectives: cisplatin is an effective anticancer drug which has some side effects such as acute kidney injury. myrtenol, a monoterpene alcohol which is found in some plants, has various pharmacological effects including anti-inflammatory and antioxidant activities. in this study, we evaluated the nephroprotective effects of myrtenol in acute kidney injury induced by cisplatin in male mice. methods: in this experimental in-vivo study, 35 male mice were randomly separated into 5 groups, including control, cis (20 mg/kg cisplatin, intraperitoneally on day 1), dimethyl sulfoxide (dmso; received cisplatin only on day 1, plus dmso 1% on the first day, continued for 3 days), and treatment groups (received cisplatin only on day 1, plus myrtenol 25 mg/kg and 50 mg/kg intraperitoneally on the first day, continued for 3 days). the blood urea nitrogen (bun) levels were evaluated in serum. the renal tissues were collected for evaluating malondialdehyde (mda), superoxide dismutase (sod), and catalase (cat) activities; histopathological investigation was also performed. results: our results showed that cisplatin administration caused significant elevation in the levels of renal mda and serum bun; in contrast, renal sod and cat activities significantly reduced. myrtenol treatment, especially 50 mg/kg for four consecutive days mitigated these alternations in serum and renal tissue. also, the kidney’s histopathological investigations were consistent with biochemical and oxidative parameters. conclusion: the results of our study revealed that myrtenol ameliorates acute kidney injury induced by cisplatin via oxidative stress suppression.