tumorigenesis inhibition of carnosol from rosemary: an insight to molecular targeting

Background and objectives: anti-proliferative activity of carnosol from rosemary on malignancies has revealed its potential for cancer therapeutic purposes. molecular studies such as proteomics could open a new insight in underling mechanisms of anticancer processes of carnosol treatment through analysis of the most relevant modulated proteins in cancer. methods: protein-protein interaction (ppi) network analysis of adult t-cell leukemia/lymphoma (atl) treated with carnosol proteome was conducted. cyroscape and its plug-ins explored the ppi network construction and its features including centrality and gene ontology. results: among 22 differentially expressed proteins (deps), 21 individuals were recognized by the string database. the queried deps and the added first neighbors formed a scale-free network. gapdh, tpi1, eno1, and pgk1 were identified as the hub-bottlenecks of the ppi network of carnosol-treated atl. conclusion: aldoa, pfkfb3, pkm2, and ldha and related metabolic processes are targets of anticancer compounds of rosemary extract; however, more investigation is suggested.