iridoid and furanolabdane-type diterpene glycosides from rhizomes of eremostachys azerbaijanica rech. f.

Background and objectives: the rhizomes of eremostachys azerbaijanica rech. f., as an indigenous plant in east azerbaijan province of iran, were studied for isolation and identification of possible phytoconstituents. methods: the air- dried and ground rhizomes were extracted with n-hexane, dichloromethane (dcm) and methanol (meoh) using a soxhlet apparatus. the 10%, 20% and 80% meoh in water c18 cartridge solid phase extraction products )sep-pak fractions( of the meoh extract were subjected to preparative reversed- phase high performance liquid chromatography (rp-hplc) and the isolated pure compounds were identified by one- dimensional nuclear magnetic resonance (1d-nmr) spectroscopic technique. results: the spectroscopic data of the compounds were compared with the respective published data and the obtained results showed the presence of four pure components, 6 - hydroxy loganin (1), shanzhiside methyl ester (2), eremostachiin (β-d-glucopyranosyl-(1→2)-β-d-glucopyranosyl ester of phlomisoic acid) (3) and phlomisoside ii (4), with iridoid and furano labdane- type diterpene glycoside structures. conclusion: the occurrence of these types of chemical structures might be a confirmation to close relation and similar pharmacological and biological activities between eremostachys and phlomis genera.