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   Resveratrol Suppresses Cardiac Renin Angiotensin System in the Late Phase of Left Ventricular Hypertrophy  
   
نویسنده Hashemizadeh Tahmineh ,Pedarzadeh Ali ,Naghedi Aryan ,Dorri Mashhadi Fahimeh ,Zavvar Reza Javad ,Safari Fereshteh ,Safari Fatemeh
منبع Research Journal Of Pharmacognosy - 2019 - دوره : 6 - شماره : 2 - صفحه:25 -37
چکیده    Background and objectives: resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a natural polyphenole phytoalexin which exerts potential cardioprotective effects, but the cellular and molecular mechanisms responsible for these effects are still unknown. cardiac renin angiotensin system (ras) over-activation plays an important role in pathogenesis of left ventricular hypertrophy (lvh) progression. the aim of the study was to investigate the effects of resveratrol on the main components of ras during early and late phase of myocardial hypertrophy. methods: to consider the early and late phase of lvh, the rats were studied two and sixteen weeks after abdominal aorta banding without treatment (h2w and h16w groups, respectively) or with resveratrol (r) treatment. intact animals served as control (ctl). arterial blood pressure was recorded by carotid cannulation. angiotensin ii (ang ii) level was measured using elisa kit. gene expression was evaluated by real time rt-pcr technique. cardiomyocyte size and fibrosis were assessed using haematoxylin/eosin and masson trichrome staining, respectively results: results of this study showed that in h2w group at1a mrna level was increased significantly (p<0.05 vs. ctl). in h16w group cardiac level of ang ii and also renin, angiotensinogen, and at2r mrna levels were increased significantly (p<0.001 vs. ctl). in h16w+r group, tissue concentration of ang ii as well as renin and angiotensinogen mrna level decreased significantly compared with h16w group (p<0.001, p<0.5 and p<0.05 ,respectively). conclusion: progression of lvh is accompanied by dynamic changes in ras components expression in myocardial tissue. resveratrol protects the heart against pressure overload-induced hypertrophy in part via ras suppression.
کلیدواژه Left Ventricular Hypertrophy ,Renin-Angiotensin System ,Resveratrol
آدرس Shahid Sadoughi University Of Medical Sciences, Faculty Of Medicine, Department Of Physiology, ایران, Shahid Sadoughi University Of Medical Sciences, Yazd Cardiovascular Research Center, ایران, Shahid Sadoughi University Of Medical Sciences, Faculty Of Medicine, Department Of Physiology, ایران, Shahid Sadoughi University Of Medical Sciences, Faculty Of Medicine, Department Of Physiology, ایران, Shahid Sadoughi University Of Medical Sciences, Faculty Of Medicine, Department Of Biochemistry, ایران, Shiraz University, School Of Veterinary Medicine, ایران, Shahid Sadoughi University Of Medical Sciences, Faculty Of Medicine, Department Of Physiology, ایران. Shahid Sadoughi University Of Medical Sciences, International Campus, Biotechnology Research Center, ایران
پست الکترونیکی f.safari@ssu.ac.ir
 
     
   
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