Comparison of Zataria multiflora Extract Syrup and Diphenhydramine in the Treatment of Common Cold-Induced Cough in Children: A Double-Blind, Randomized, Clinical Trial

Background: management of cold-associated cough is a challenging aspect of supportive care for the common cold for pediatriciansand parents worldwide. herbalcompoundshave traditionally been used for the treatment of cold-related cough. amongthese compounds, zataria multiflora (zm) has been found to be effective for cough relief. objectives: the aim of this study is to compare a thyme mixture with diphenhydramine in the treatment of cold-related cough in a double-blind, randomized, clinical trial. patients and methods: a total of 52 pediatric patients (2 - 12 years old) with common colds were included in the study. the patients were randomly divided into two treatment groups: one group received diphenhydramine compound and the other received zm syrup, each for five days. the severity of cold-related symptoms and the efficacy of each drug were determined seven days later by asking the parents to complete a prepared questionnaire. sedation, sleepiness, a four-point scale of cough status, and a two-point scale of consumption convenience were also evaluated in these questionnaires. results: our results showed that sedation and sleepiness occurred in 30.8% and 19.2% of the patients in the diphenhydramine and zm groups, respectively (p = 0.54). also, 65.4% and 84.6% of the patients in the diphenhydramine and zm groups, respectively, reported convenient usage (p = 0.10). the patients who received zm syrup had significantly better outcomes (p = 0.036). conclusions: herbal compounds, such as zm mixtures, are acceptably efficacious in cough relief with fewer adverse effects than chemical compounds in the treatment of cold-related cough, especially in infants and younger children