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Interleukin-1 as a Key Factor in the Development of Inflammatory Diseases
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نویسنده
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Farivar Shirin ,Hassani Mahdieh ,Shiari Reza
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منبع
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archives of pediatric infectious diseases - 2014 - دوره : 2 - شماره : 4 - صفحه:1 -5
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چکیده
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High levels of interleukin-1 have been implicated in uncontrolled inflammation and fever in inflammatory diseases, including; familial mediterranean fever, cryopyrin associated periodic syndrome, behcet's disease and systemic onset juvenile idiopathic arthritis. the underlying specific genetic causes for these diseases have not yet been elucidated due to inferring factors, such as high levels of interleukin-1 beta (il-1β) in the blood and etiology, as well as the disease manifestations. conclusions: this review discusses the role of interleukin-1 beta and interleukin-18 production pathways in the development of systemic onset juvenile idiopathic arthritis and familial mediterranean fever disease.
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کلیدواژه
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Autoimmune Diseases; Interleukin 1 Receptor Antagonist Protein; Cytokines
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آدرس
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shahid beheshti university of medical sciences, Faculty of Biological Sciences, Laser and Plasma Research Institute, Department of Genetics, ایران, shahid beheshti university of medical sciences, Faculty of Biological Sciences, Department of Genetics, ایران, shahid beheshti university of medical sciences, Mofid Children’s Hospital, Pediatric Infections Research Center, Department of Pediatric Rheumatology, ایران
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پست الکترونیکی
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shiareza@yahoo.com
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Authors
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