efficacy of zinc as adjuvant therapy in the treatment of severe pneumonia in hospitalized children: a randomized clinical trial

Background: pneumonia remains one of the leading causes of childhood mortality and morbidity in developing countries. studies showed that zinc supplementation can prevent pneumonia, but its therapeutic effectiveness has not been determined definitively. objectives: this study evaluated the effect of zinc supplementation as adjuvant treatment on children with severe pneumonia admitted to 17th shahrivar training hospital in rasht, iran. methods: in this double-blind placebo-controlled clinical trial, 120 children aged two to 60 months hospitalized for pneumonia were randomly divided into 2 groups of size 60 each. the first group received zinc sulfate (20 mg daily for children twelve months of age or older and 10 mg daily for children younger than 12 months), and the second group received a placebo for seven days. all patients received standard antibiotic treatment for pneumonia. the children were daily evaluated, and recovery time for fever and tachypnea (as primary outcomes) and duration of hospitalization and mortality rate (as secondary outcomes) were compared between the two groups. results: the meanage of patients was 14.1 months13.9. the youngest and oldest patients were aged 2 and 60 months, respectively. no significant difference in age and sex distribution was found between the two groups. the zinc receiving group experienced a considerably shorter time of fever (2.1 days vs. 2.84 days, p < 0.05) and tachypnea (1.75 days versus 2.1 days, p = 0.011). there was no significant difference in the duration of admission between the two groups (p = 0.728), and no cases of death occurred in either group. conclusions: this study showed that adjuvant treatment with zinc in children aged 2 to 60 months with severe pneumonia accelerates recovery from pneumonia. further studies are needed to investigate the effects of administering zinc as adjunctive therapy for pneumonia in other age groups.