the association of helicobacter pylori infection with endothelial dysfunction in pediatric patients

Objectives: the aim of this study was to evaluate endothelial dysfunction in pediatric patients with helicobacter pylori infection. methods: in a cross sectional study, 50 children between six and twelve years old were evaluated for helicobacter pylori infection by a histopathologic specimen. c-reactive protein (crp) and interleukin -12 of all subjects was checked. endothelial dysfunction was evaluated by echocardiography of brachial artery and through measuring flow mediated dilatation (fmd). results: mean of fmd level was significantly higher in children with h. pylori infection (p value: 0.04). interlukin-12 (il-12) was higher in children with h. pylori infection (p value: 0.04). linear regression showed a positive association of helicobacter pylori infection and endothelial dysfunction (beta = 0.3, p value = 0.08). conclusions: children with helicobacter pylori infection have more endothelial dysfunction independent of il-12.