the acute effect of inhaled nacl 5%, per cf trust protocol, on spirometry indices in patients over six years with cystic fibrosis

Background: our aim was to investigate the acute effect of inhaled nacl 5% on spirometry indices in patients aged over six years with cystic fibrosis (cf). methods: 44 children over 6 years of age with cf took part in this study. spirometry indices were measured. after receiving two puffs of salbutamol spray, the children were administered with 5 ml nacl 5% by a medical compressed air system using a nebulizer kit and immediately a spirometric test was taken again. spirometry results were recorded and the data were analyzed by spss v.18. results: the percentages of the annual decline of forced expiratory volume in one second (fev1 ) were 10.12 ± 31.28, 7.26 ± 17.10, and 13.8 ± 21.7 in children aged 6 8 years, 9 12 years, and over 13 years, respectively. there were significant differences in fvc, fev1 /fvc, mef50 , mef75 , mmef25/27 before and after hypertonic nacl 5% inhalation (p < 0.05). a significant decline in fev1 was observed only in 2% of the children. conclusions: patients with cf exhibited a suitable response to acute inhalation of hypertonic nacl 5%.