Membrane Stabilizing Activity & Protein Denaturation A Possible Mechanism of Action for the Anti-Inflammatory Activity of Phyllanthus Amarus

Background: previous studies confirm the anti-inflammatory potential of phyllanthus amarus herb. aim and objective: primary aim of the present study was to investigate the possible anti-inflammatory mechanism of phyllanthus amarus extract using in-vitro models. material & method: aqueous extract of phyllanthus amarus was evaluated in vitro models for haemolysis of erythrocytes and % inhibition in heat induced protein denaturation at three doses 50 mg/kg, 100 mg/kg & 200 mg/ kg. results: the aqueous extract of phyllanthus amarus significantly inhibited the haemolysis of erythrocytes and heat induced protein denaturation as compared to control. conclusion: it can be postulated from the observed results that the anti-inflammatory activity of phyllanthus amarus could be due to its membrane stabilizing action and inhibition of protein denaturation