Role of C-peptide in altered lipid profile among apparently healthy adults of Vijayapura city,Karnataka

Background: c-peptide is produced in equimolar concentration during insulin production as inactive molecule by beta islet cells of langerhans. c-peptide is most useful biomarker of endogenous insulin production. aim and objectives: to predict metabolic syndrome in advance by estimation of c-peptide and lipid profile in healthy adults. material and methods: serum c-peptide,fasting blood glucose and lipid profile of 128 healthy individuals were estimated. adults in the age group of 18 to 60 years of both sexes were included in study. results: c-peptide levels were increased in 27%,serum cholesterol in 30%,ldl cholesterol in 55% and triglyceride levels in 21% of healthy individuals. significant correlation was observed between c peptide,age,serum cholesterol,ldl and cholesterol ldl ratio in male subjects only. in our study group most of the subjects (both males and females) fell in overweight group. conclusion: cpeptide level and lipid profile may be considered as useful biomarkers to predict type 2 diabetes mellitus in advance,possibly due to insulin resistance. © journal of krishna institute of medical sciences university.