Antinociceptive effect of ondansetron in Albino mice using acetic acid induced writhing model

Background: pain is an unpleasant sensory and emotional experience. pain is a protective mechanism. pain occurs whenever any tissues are being damaged,and it causes the individual to react and to remove the pain stimulus. aim and objectives: to evaluate the antinociceptive effect of ondansetron in comparison with the standard diclofenac. material and methods: the antinociceptive effect was tested by using the acetic acid induced writhing model in swiss albino mice. animals were divided into 4 groups of 6 animals each. animals were received distilled water (control),diclofenac (standard),ondansetron 0.5mg/kg (test i) and ondansetron 1mg/kg (test ii). after 30 minutes of drug administration,0.1 ml of 1% acetic acid was injected. mice were placed individually into glass beakers and five minutes were allowed to elapse. they were then observed for a period of ten minutes and the numbers of writhes were recorded in each animal. the results were expressed as mean ± sem. one way anova with post-test was used for statistical calculation. results: the numbers of writhes were 1.33±0.494 for diclofenac; 6.33±1.872 and 9.33±1.706 for ondansetron 0.5 and 1mg/kg respectively. conclusion: ondansetron demonstrated statistical significant antinociceptive activity at both doses (0.5mg/kg and 1mg/kg) and statistically similar effect as diclofenac. © journal of krishna institute of medical sciences university.