Association of genetic variants in hoGG1 and APE1 genes with breast cancer risk in a rural population: A hospital based case-control study

Background: breast cancer (bc) is a major concern of health risk in urban and rural areas of india. aim and objectives: this study was aimed to find out the frequency of polymorphisms in dna repair genes,human 8-oxoguanine dna glycosylase 1 (hogg1) at codon (cd) 326 and apurinic/apyrimidinic endonuclease 1 (ape1) at cd 148 in patients of bc from maharashtra and to evaluate their association with bc development. material and methods: we used polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) to examine gene polymorphisms in 170 patients with bc and 200 in age and sex matched disease-free controls. results: the results indicated that there was no significant difference in the genotype distribution between bc patients and controls for hogg1 (p>0.05). the result showed that allele frequencies of ape1 glu148 (or=4.78; 95% ci= (2.55-8.95); p= <0.0001) genotype significantly increased the risk of bc. conclusion: this study indicates that polymorphisms in cd148 of ape1 gene could play a role in modifying genetic susceptibility of individual to breast cancer in maharashtrian patients. © journal of krishna institute of medical sciences university.