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Green synthesis and biological evaluation of steroidal 2H-pyrans as anticancer and antioxidant agents
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نویسنده
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shamsuzzaman steroid research laboratory ,mashrai a. ,khanam h. ,asif m. ,ali a. ,sherwani a. ,owais m.
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منبع
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journal of king saud university - science - 2015 - دوره : 27 - شماره : 1 - صفحه:1 -6
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چکیده
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In this study,we describe a green and simple procedure for the synthesis of steroidal 2h-pyrans 4-6 using chitosan as an eco-friendly heterogeneous catalyst. the synthesized compounds were characterized by ir,1h nmr,13c nmr,ms and analytical data. these compounds were tested in vitro against two cancer cell lines [hela (cervical) and jurkat (leukemia)] and one normal cell line (pbmc). the compounds exhibited moderate to good activity against the two human cancer cell lines and were less toxic against the non-cancer cell line. in addition,the synthesized compounds were tested for their in vitro antioxidant activity by 1,1-diphenylpicrylhydrazyl method in which compounds 4 and 6 exhibited good antioxidant activity. this study provided a new molecular scaffold for the further development of anticancer as well as antioxidant agents. © 2013 king saud university.
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کلیدواژه
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2H-pyran; Anticancer; Antioxidant; Chitosan; Green chemistry
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آدرس
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department of chemistry,aligarh muslim university, India, steroid research laboratory,department of chemistry,aligarh muslim university, India, steroid research laboratory,department of chemistry,aligarh muslim university, India, steroid research laboratory,department of chemistry,aligarh muslim university, India, steroid research laboratory,department of chemistry,aligarh muslim university, India, interdisciplinary biotechnology unit,aligarh muslim university, India, interdisciplinary biotechnology unit,aligarh muslim university, India
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Authors
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