Synthesis, characterization and effect of bis-1,3,4-oxadiazole rings containing glycine moiety on the activity of some transferase enzymes

We described herein the synthesis of bis-1,3,4-oxadiazole containing glycine moiety. n-{5-[5-(4-methoxyphenyl)-1,3,4-oxadiazole-2-yl-sulfanyl]-1,3,4-oxadiazole-2-yl-methyl}-4-methoxybenzamide was fully characterized by elemental analysis, ft-ir and h nmr spectroscopy. also this study was designed to show the effects of bis-oxadiazole compound on the activities of some transferase enzymes such as: got, gpt and c-gt in sera. this compound demonstrated activation on got and gpt activities, inhibitory effects on the c-gt activity. these effects increased with increasing the concentration of the compound. the causes of the increases and decreases in the enzymes activities are discussed.