the severity of covid-19 infection correlation with il-17 polymorphism

Single nucleotide polymorphisms (snps) in many studied genes have been related to the severity of covid-19. this study was carried out to investigate whether the polymorphisms of two snps (rs763780 and rs2275913) of the gene polymorphisms for interleukin 17 (il-17) are connected to the covid-19 severity. the effect of these polymorphisms on the levels of il-17 and the relationship between the level of il-17 and the severity of covid-19 were also investigated. the real-time polymerase chain reaction (rt-pcr) was performed to detect sars-cov-2. blood samples were obtained for the analyses of il-17 levels by enzyme-linked immunosorbent assay, and genomic dna was extracted for genotyping. it should be noted that genotyping was performed using rt-pcr. the results indicated that the il-17 level significantly increased in the case group, compared to the control group (healthy people), and there was a relationship between the severity of covid-19 and il-17 levels (p0.05) and critical group (p=0.023, p>0.05), compared to the mild group. there was no relationship (p0.05). both of them increased the risk in all groups, including the mild or moderate group (p=0.0001, p>0.05), the severe group (p=0.0001, p>0.05 for tc genotype and p=0.04, p>0.05 for cc genotype), and critical group (p=0.0001, p>0.05). according to the results, covid-19 prognosis and severity were substantially correlated with il-17 level and two il-17 snps, rs2275913 and rs763780. it demonstrated that the two snps might be potential markers for the prediction of covid-19 risk and development. the different levels of severity also had a non-significant relationship with snp13 and snp80 as well as il-17 levels (ng/l).