interleukin-1β rs1143634 polymorphism and susceptibility to periodontitis in the iraqi population

Periodontitis is a complex multifactorial inflammatory disease, and its genetic basis has been studied. the interleukin-1 beta (il-1β) is a crucial proinflammatory mediator in the pathogenesis of periodontitis with high polymorphism. this study aimed to investigate whether the rs1143634 genetic variant of the il-1β gene is associated with an increased risk for periodontitis. for this purpose, genotyping of the il-1β rs1143634 polymorphism was performed using the polymerase chain reaction-restriction fragment length polymorphism method on 90 patients within the age range of 35-60 years old. they were divided into two groups: 64 periodontitis cases (stage 3 and 4 periodontitis according to 2017 classification) and 26 racially matched healthy cases as the control group. fisher’s exact test showed a significant decrease in tt homozygous genotype in periodontitis cases, compared to the control group (p=0.018), suggesting that this genotype is a protective factor in the test population. allele frequency showed an elevated odd ratio (1.24) and increased risk for periodontitis in subjects with allele c and reduced odd ratio (0.81) and reduced risk for periodontitis in subjects with allele t. allele t of il-1β rs1143634 polymorphism could be a protective factor, while allele c of this polymorphism could be a risk factor for periodontitis in the studied iraqi population.