the association of serum calcium and vitamin d with insulin resistance and beta-cell dysfunction among people with type 2 diabetes

Cross-sectional studies have linked vitamin d deficiency and alteration of calcium levels to an increased incidence of type 2 diabetes and insulin resistance. this study investigated a possible correlation between blood vitamin d and calcium levels with insulin resistance and beta-cell dysfunction in type 2 diabetes, pre-diabetes, and healthy individuals. this cross-sectional study involved 300 participants. participants were divided into three groups (n=100), type 2diabetic, prediabetic, and healthy. in order to measure insulin resistance and β –cell function, the homa ir and homa b were assessed, respectively. also, the other parameters such as serum 25(oh)d, blood insulin (fpi), glucose (fbs), hba1c, and calcium were assessed in this study. in simple regression analysis, a high vitamin d level is linked to lower levels of fbs, hba1c, insulin, and homa ir, and higher levels of homa b. calcium has a positive connection with fbs and hba1c and a negative connection with insulin level and homab. hypovitaminosis d may substantially influence diabetes patients’ glycemic dysregulation. an increased incidence of type 2 diabetes has been related to a disruption in calcium homeostasis. all in all an increament in calcium levels may have a role in developing type 2 diabetes.